Chloroquine-resistant falciparum malaria from Africa.

FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of limited value. All malariologists have dreaded the day when chloroquine-resistant malaria from Africa would be described.1 Alas, evidence presented in two case reports would indicate that the day is here.